Prenatal screening and NIPT with Femme Amsterdam
At Femme Amsterdam we offer prenatal screening. Thanks to these tests, we can determine whether your baby is at risk for certain conditions or disorders. Prenatal screening is not obligatory, it’s your own choice if you want to do the screening or not. Our midwives can provide further information specific to your situation so you can choose wisely if you want to do these tests or not.
If one of the prenatal tests identifies an increased risk of a chromosomal or genetic disorder, you can conduct prenatal diagnosis. These tests provide certainty concerning whether your baby has a disorder. There are two types of prenatal diagnosis:
- CVS – a small sample of placenta tissue is removed and analysed
- Amniocentesis – a small sample of amniotic fluid is drawn and analysed
These tests are invasive, which means there is a small chance of miscarriage. The chance of this occurring is 1:200 for CVS and 1:300 for amniocentesis.
FREQUENTLY ASKED QUESTIONS
A blood sample is taken for each of the tests. At the combined test we also make an ultrasound between week 11,5 and 13,5. This is for measuring the fold of the neck.
Nederlandse NIPT: Yes, this test is used in scientific research. You will provide permission for the use of your data. If you do not provide permission, you will not be able to undertake the Dutch NIPT because this test includes automatic participation in a research study. To be able to choose for the Dutch NIPT you need to have a personal security number (BSN).
Combinatietest: No, your data is not used for scientific research for this test. It has been available in the Netherlands for many years.
Nederlandse NIPT: For the Dutch NIPT, the so-called counting method is used. The number of chromosomes in the DNA found within the placenta is counted. This method cannot be used for twins or multiples.
Combinatietest: The Combined test determines the level of PAP-A and βHcG hormones via a blood sample. Coupled with the thickness of the fluid at the back of your baby’s neck, the values of these hormones predict the risk of a chromosomal disorder.
Nederlandse NIPT: From 11 weeks’ gestation
Combinatietest: Blood sample can be taken between 9 and 14 weeks’ gestation and the ultrasound between 11 and 13 weeks’ gestation.
Nederlandse NIPT: Within 12 days
Combinatietest: 2 days after the ultrasound if the blood sample was taken one week in advance.
Nederlandse NIPT: No, the test identifies:
- 97 out of 100 children with trisomie 21
- 90 out of 100 children with trisomie 18
- 90 out of 100 children with trisomie 13
NIPT’s Trident-2 study is still ongoing. These results are based on 72,340 studies.
Combinatietest: No, the test identifies:
- 85 out of 100 children with trisomie 21
- 77 out of 100 children with trisomie 18
- 65 out of 100 children with trisomie 13
Nederlandse NIPT: €175. Tests for chromosome 13, 18, 21 with an option to investigate other genetic abnormalities.
Dutch NIPT: When the results indicate an increased risk of:
- Trisomy 21, there is a 75% chance of the baby having trisomy 21 and a 25% chance that the baby does not have trisomy 21.
- Trisomy 18, there is a 24% chance of the baby having trisomy 21 and a 76% chance that the baby does not have trisomy 18.
- Trisomy 13, there is a 23% chance of the baby having trisomy 21 and a 77% chance that the baby does not have trisomy 13.
Combinatietest: With the combined test, you will receive a result presented as 1 out of …. This is the risk of your baby having trisomy 21, 18 and 13. If the result is 1 out of 5 up to 1 out of 200, you qualify for the Trident-1 study (the Dutch NIPT). If that also presents an increased risk, you may choose to proceed with prenatal diagnosis.
Nederlandse NIPT: When the results indicate that there is not an increased risk of:
- Trisomy 21, 18 and 13: There is a 99% chance that the baby does not have trisomy 21, 18 and 13 and a 1% chance of the baby having trisomy 21, 18 and 13.
Nederlandse NIPT: No. However, physical abnormalities are occasionally identified during the ultrasound.